Trends in On-label and Off-label Modafinil Use in a Nationally Representative Sample

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Trends in on-label and off-label modafinil use in a nationally representative sample.

search, Department of Medicine, Baylor College of Medicine, Houston (Drs Singh, Petersen, and Sawhney); Department of Psychology, University of Houston, Houston (Dr Spitzmueller); and School of Biomedical Informatics and University of Texas–Memorial Hermann Center for Healthcare Quality and Safety, University of Texas Health Science Center at Houston (Dr Sittig). Correspondence: Dr Singh, Micha...

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Off-Label Use of Pharmaceuticals: Trends and Drivers

We identify the rate of off-label use of prescription drugs in the United States during 1993-2008. We apply Detection Controlled Estimation to a comprehensive crosssection of prescriptions and find that rates of off-label use rise from 30.2% to 39.1% during this period. This coincides with a surge in settlements of Department of Justice lawsuits for off-label marketing. Additionally, physicians...

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Use of Salvia divinorum in a nationally representative sample.

BACKGROUND Salvia divinorum has known hallucinogenic effects and is legal in most parts of the United States. Given that this psychoactive substance has a potential of misuse and abuse, further data regarding the clinical and psychosocial factors associated with use are needed. OBJECTIVES To examine the clinical and psychosocial characteristics associated with use of salvia. METHODS The stu...

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[Challenges on off label medicine use].

p After the Second World War, the so-called pharmacological explosion took place, leading to major advances in the treatment of diseases that were once inevitably fatal or disabling. This pharmacological expansion contributed to the occurrence of catastrophic incidents, such as the phocomelia epidemic attributed to thalidomide. Since then, concerns about drug safety have contributed to the deve...

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Off-label use of misoprostol in gynaecology

Clinical use of drugs is approved for specified clinical indication, route of administration, dose and population group. Off-label prescribing of a registered medicine occurs outside of these parameters and may be justified by pharmacology and physiology, as well as sufficient evidence from published clinical trials and reviews. Misoprostol and mifepristone in combination have recently been reg...

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ژورنال

عنوان ژورنال: JAMA Internal Medicine

سال: 2013

ISSN: 2168-6106

DOI: 10.1001/jamainternmed.2013.2807